Main Category: Immune System / Vaccines
Also Included In: Respiratory / Asthma; Arthritis / Rheumatology; Multiple Sclerosis
Article Date: 10 Oct 2011 – 0:00 PDT
email to a friend printer friendly opinions
<!– rate article
Patient / Public:
2.5 (2 votes)
Researchers have discovered a cellular pathway that promotes inflammation in diseases like asthma, rheumatoid arthritis, psoriasis, inflammatory bowel disease, and multiple sclerosis. Understanding the details of this pathway may provide opportunities for tailored treatments of inflammatory and autoimmune diseases.
Discovery of this pathway was the work of an active collaboration between Xiaoxia Li, Ph.D., and Thomas Hamilton, Ph.D., Department Chair, both of the Department of Immunology at Lerner Research Institute of Cleveland Clinic.
Their publications in Nature Immunology, selected for a News and Views article in the same issue, portray how a protein molecule known as interleukin-17 (IL-17) spurs inflammation by recruiting specific white blood cells to sites of infection and injury, producing a strong, pathogenic response.
Being able to block this pathway may treat IL-17-induced inflammatory diseases. Molecular factors discovered by Li and Hamilton make this concept a potential strategy.
“We are excited by the possibilities that this new research opens up for developing improved therapeutics for these difficult diseases,” Hamilton said.
“Being able to collaborate like this really expedites the science,” Li added, “ultimately leading, we hope, to profound improvement for those suffering from these autoimmune and inflammatory conditions.”
Please use one of the following formats to cite this article in your essay, paper or report:
Please note: If no author information is provided, the source is cited instead.
Please note that we publish your name, but we do not publish your email address. It is only used to let
If you write about specific medications or operations, please do not name health care professionals by name.
All opinions are moderated before being included (to stop spam)
Contact Our News Editors
For any corrections of factual information, or to contact the editors please use our feedback form.
Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care
professional. For more information, please read our terms and conditions.
Terms and Conditions
MediLexicon International Ltd
Bexhill-on-Sea, United Kingdom
MediLexicon International Ltd © 2004-2011 All rights reserved.